OraWize+ is a revolutionary intraoral mouthwash disinfectant used for killing higher than normal bacterial counts (cfu/ml) in the mouth and has been formulated for safe use by both dental professionals as well as patients, to help reduce high bacterial loadings back down to normal levels found in healthy mouths.
OraWize +’s active ingredient is called Hypochlorous (HOCl), which is part of a group of small molecules known as reactive oxygen species (ROS). It is synthesized by immune system cells (white blood cells) during phagocytosis of antigens 1. The molecule consistently shows a broad antimicrobial spectrum for the inhibition of multiple Gram positive and Gram negative microorganisms, without causing side effects such as irritation of the mucosa or extrinsic pigmentation on the tooth surface or restorations. In addition, HOCl also has an important anti-inflammatory and proliferative activity (2 3 4 ).
Ingredients: 99.58% water, NaCl 0.4% and Hypochlorous 0.02%. Plus oxygen Nano bubbles.
Contains 0-01-0.02% w/v Hypochlorous Acid.
Instruction for Use: Rinse with around 20ml of OraWize for one minute, spit out and repeat. Don’t rinse with water afterwards.
Use twice a day or after a meal.
Alcohol free. Aldehyde free. 250ml bottle.
Green JN, Kettle AJ, Winterbourn CC. Protein chlorination in neutrophil phagosomes and correlation with bacterial killing. Free Radic Biol Med 2014;77:49-56.
Wang L, Bassiri M, Najafi R, Najafi K, Yang J, Khosrovi B, et al.. Hypochlorous acid as a potential wound care agent: Part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. J Burns Wounds 2007;11;6:e5.
Fu X, Kassim SY, Parks WC, Heinecke JW.Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammation. J Biol Chem 2003;278:28403-28409.
Kim C, Cha YN. Taurine chloramine produced from taurine under inflammation provides anti-inflammatory and cytoprotective effects. Amino Acids 2014;46:89-100.